Work with us

Long Island City, NY · Onsite, Full-Time · Reports to CTO

$125,000–$170,000/year, plus equity and benefits. Must be authorized to work full-time in the US.

About Claryx

Claryx is building the hospital immune system, reading the genomes of confirmed patient infections, linking related cases as outbreaks, and tracing each back to its likely source. When that source is in the building (a sink, a shared piece of equipment, a particular room), Claryx finds it by matching the patient's strain against a digital twin of the hospital's microbiome, sequenced from its air, its water and its surfaces, all on proprietary chemistry cheap enough to run continuously. Founded by brothers Kurt and Dirk Hackenberger, Claryx is based in New York and is live across multiple health systems.

The Role

We’re hiring a Computational Scientist to take over Claryx’s inference platform: the models that turn sequence data from patient infections and environmental samples into a defensible claim about what came from where, and when.

The list below is in priority order for the first year, with a specific focus on modelling and inference. The platform and security posture underneath it come with the role, but Drata supports them, and we don’t expect you to arrive with deep expertise. We’re early-stage, so whoever takes this role will set technical direction rather than follow it and use existing agentic coding tools to maximize output.

Key Responsibilities

• Transmission attribution. Predict transmission pathways under incomplete sampling over a facility represented as a network of reservoirs.

• Phylogenetic inference. Time-resolved trees, structured coalescent and birth–death models, ancestral state reconstruction, recombination-aware alignment, across clinical and environmental samples together.

• Bioinformatics pipelines. Running and hardening our metagenomic and comparative genomics pipelines, from QC through strain-level comparison between clinical isolates and environmental samples.

• Metagenomic inference. Strain-level deconvolution of mixed environmental populations.

• Cloud infrastructure. AWS environment. Solidify infrastructure-as-code, proper CI/CD, predictable costs.

• Compliance. Deepen HIPAA/SOC 2 controls to maintain compliance and remain audit-ready.

• Results communication. Move reporting off static outputs onto an interactive dashboard.

Qualifications

• PhD in mathematical biology. Population genetics, molecular evolution, biostatistics, genomic epidemiology.

• Mathematics. Deep knowledge of Likelihood and Bayesian inference, MCMC, continuous-time Markov chains, coalescent and birth-death processes, identifiability, model selection, etc.

• Machine and deep learning. Understand backpropagation and optimization. Simulation-based inference and posterior estimation. GNNs and other network representations are a plus.

• Phylogenetics. BEAST, IQ-TREE or equivalents. Transmission-tree tools are a plus.

• AWS, Linux/bash, Git. Nextflow preferred for workflows. AWS in production – IAM, S3, Batch, Terraform.

• Agentic coding tools. Structuring problems, managing context, reading generated code critically.

Practicalities

For strong performers, this role is designed to grow into our Head of Computational Science, expanding across the inference and data stack and eventually taking on a team. You’d report to the CTO and work closely with our molecular epidemiologist and the wet lab. It’s fully onsite in Long Island City, in the same space as the lab generating the data.

We publish and work with academic groups, nonprofits and public health labs, and we'd want you publishing too, so the methods you build here end up in the literature as well as in production.

How To Apply

Send a resume and a short note about why this role interests you to careers@claryx.com with “Claryx – Computational Scientist Application” as the subject line.

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Long Island City, NY · Onsite, Full-Time · Reports to Laboratory Lead

$68,000–$82,000/year, plus equity and benefits. Must be authorized to work full-time in the US.

About Claryx

Claryx is building the hospital immune system, reading the genomes of confirmed patient infections, linking related cases as outbreaks, and tracing each back to its likely source. When that source is in the building (a sink, a shared piece of equipment, a particular room), Claryx finds it by matching the patient's strain against a digital twin of the hospital's microbiome, sequenced from its air, its water and its surfaces, all on proprietary chemistry cheap enough to run continuously. Founded by brothers Kurt and Dirk Hackenberger, Claryx is based in New York and is live across multiple health systems.

The Role

We’re hiring a Laboratory Technician to help run our existing molecular workflow: nucleic acid extraction from complex environmental samples and isolates, qPCR panels, and library prep for sequencing. It’s a hands-on support role alongside our Laboratory Lead, and the main job is keeping that workflow running reliably as sample volume grows.

Our partner hospitals send samples on their schedule, so collection, extraction, assays and sequencing each have to happen in a set window, and everything downstream, from the analysis to what goes back to the hospital, depends on that timing holding. You don't need to have done every step before, we're happy to train someone careful and reliable.

Key Responsibilities

• Sample processing. Accession incoming samples and take them through extraction across air, water, surface and swab matrices, under strict contamination control.

• Molecular assays. Run qPCR/RT-qPCR panels for our priority pathogens and resistance targets, plus library prep for sequencing.

• Automation. Operate an automated liquid handler and help move manual steps onto it.

• Field collection. Scheduled sample pickups from partner hospitals, maintaining chain of custody.

• Lab operations. Inventory, reagent prep, instrument upkeep, and complete ELN/LIMS records.

• Optimization. Identify workflow steps that can be improved and develop/test modifications.

Qualifications

• B.S. or higher. Molecular biology, microbiology, biochemistry, or similar. 0-2 years of hands-on experience, including laboratory work for grad school. BSL-2 experience is a plus.

• Core molecular techniques. Nucleic acid extraction and qPCR. Library prep, protein purification, and automated liquid handling experience are a plus.

• Careful record-keeping. ELN/LIMS discipline to maintain strong documentation of all samples.

• Valid driver’s license. The role includes scheduled sample pickups.

Practicalities

You'd start by running the workflow and grow into assay development, QC ownership and the automation build-out (Research Associate, then Senior Research Associate), then train and lead the people we hire after you. For the right person the path runs all the way to Laboratory Director, running the lab and the team as we expand from a few NYC hospitals to health systems across the country. You’d report to the Laboratory Lead and work closely with our computational team. It’s fully onsite in Long Island City. The work is BSL-2 and includes weekly travel to partner sites around New York City.

How To Apply

Send a resume and a short note about why this role interests you to careers@claryx.com with “Claryx – Laboratory Technician Application” as the subject line.

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